Jennifer Aniston and fellow big screen stars Halle Berry and Reese Witherspoon are set to appear on a major telethon in the US to support cancer research.

They will be joined by TV leading men Jon Hamm and Kiefer Sutherland on Stand Up To Cancer, the telethon set to air on September 5 on 31 broadcast and cable networks simultaneously across America.

Other celebrity participants include Hollywood A-listers Pierce Brosnan, Rob Lowe, Will Ferrell and Ben Stiller. The broadcast will also feature performances by Jennifer Hudson, Ariana Grande, The Who, Common and Lupe Fiasco and Dave Matthews.

Funds raised by Stand Up To Cancer support international scientific research aimed at discovering new treatments for various types of cancer. Since its first telethon in 2008, Stand Up To Cancer has pledged more than 260 million dollars.